In order to develop new antimicrobial agent, a series of N1- substituted 3, 5 diphenyl pyrazolines were prepared and evaluated for their antimicrobial activity. The SAR analysis showed that the antimicrobial activity was highly dependent on the substitution pattern of the aryl rings and correlated to a large extent with the ability of compounds to interact with sulfhydryl group. All the synthesized compounds have been characterized by spectral analysis and have been screened for their antimicrobial activity against Gram–ve bacteria (E.coli) of clinical relevance and also against strain of fungi (S.cerevisae). Among the prepared compounds those with electron withdrawing groups located in the p-position in the ring B, and hydroxyl group at ortho position had a powerful accelerating effect on the reactivity of the sulfhydrl group.
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